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Er zijn43resultaten gevonden
Farmacokinetiek en -dynamiek

Radiation dosimetry based pharmacokinetics and dynamics for personalized dosing in radioligand therapy

  • Universiteit Erasmus Medisch Centrum Rotterdam
  • Promovendus Kevin Doornhof
  • Promoters F.A. Verburg
  • Co-Promoters S.L.W. Koolen M.W. Konijnenberg N.H. Hendrikse
  • Jaar 2023-2027

Fixed dosing strategies are commonly used in radio-ligand therapies. Radiation dosimetry provides a method of determining radiation exposure of various tissues, allowing for dosages to be optimized for individual patients. To this end, this project explores the use of radiation dosimetry in PK/PD modeling of radiopharmaceuticals, and its use in optimizing dosing strategies.
 

Farmacokinetiek en -dynamiek

Predicting immune responses post-vaccination by PK/PD modeling as a tool for pandemic preparedness

  • Universiteit Erasmus Medisch Centrum Rotterdam
  • Promovendus Koen de Waard
  • Promoters Hugo van der Kuy
  • Co-Promoters Tim Preijers
  • Jaar 2024-2028

We aim to develop a pharmacometric model based on COVID-19 data able to identify personal characteristics that could predict individual immune response. Moreover, a framework will be established as a tool for pandemic preparedness. 
 

Farmacokinetiek en -dynamiek

Towards precision dosing in psychiatric patients

  • Universiteit Erasmus Medisch Centrum Rotterdam
  • Promovendus Lisa Ringeling
  • Promoters Birigit Koch Manon Hillegers
  • Co-Promoters Brenda de Winter Bram Dierckx
  • Jaar 2022-2026

SPACe 2: STAR: An international, multicentre, randomized controlled trial (RCT) to evaluate the effect of therapeutic drug monitoring (TDM) of antipsychotic drugs in children and adolescents.
 

Farmacokinetiek en -dynamiek

Beta-Lactam antibiotics initial exposure optimised in critically ill patients with sepsis

  • Universiteit Erasmus Medisch Centrum Rotterdam
  • Promovendus Mirte Horstink
  • Promoters Birgit Koch
  • Co-Promoters Corstiaan den Uil Nicole Deetman Rik Endeman
  • Jaar 2024-2027

We aim to improve treatment of critically ill sepsis patients by increasing beta-lactam dosages in the initial phase of sepsis. 
 

Farmacokinetiek en -dynamiek

Advancements in outpatient parenteral antimicrobial therapy services

  • Universiteit Erasmus Medisch Centrum Rotterdam
  • Promovendus Moska Hassanzai
  • Promoters Birgit Koch
  • Co-Promoters B.C.M. de Winter H.A.W. van Onzenoort
  • Jaar 2021-2025
Farmacokinetiek en -dynamiek

Pharmacometric analyses in oncology

  • Universiteit Erasmus Medisch Centrum Rotterdam
  • Promovendus Pascale Rietveld
  • Promoters Birgit Koch Ron Matthijssen
  • Co-Promoters Stijn Koolen Sebastiaan Sassen
  • Jaar 2022-2025

The aim is to personalize oncological treatments using a pharmacometric approach.
 

Productzorg en bereiding

3D printed, personalized cortisol. From idea to clinic.

  • Universiteit Erasmus Medisch Centrum Rotterdam
  • Promovendus Sejad Ayyoubi
  • Promoters Hugo van der Kuy
  • Co-Promoters Julian Quodbach Liesbeth Ruijgrok
  • Jaar 2021-2025

1. Formulation development of direct, sustained and delayed release products using FDM, SSE and automated capsule filling systems. 
2. Quality and cost considerations of 3D printing in a hospital pharmacy setting.
3. Clinical implementation and studies of personalized cortisol in patients with adrenal insufficiency.
 

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