Promotie onderzoek

The aim of this project is to achieve more effective patient treatments with antibiotics by quantifying the concentrations at the site of infection with minimal sample volumes. To enable quantification of antibiotics at the site of infection, multiple assays should be developed and validated in these infected matrices, such as synovial fluid, synovial tissue, bone, and vitreous humor. Furthermore, the focus will be on small-volume samples and more patient friendly, and sustainable sample preparations.
 

A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critically ill pediatric patients and associated risk factors.
 

This thesis explores how systemic inflammation and continuous renal replacement therapy (CRRT) influence drug pharmacokinetics in critically ill patients. Key research questions include: How does inflammation alter midazolam metabolism in critically ill COVID-19 patients? What impact does CRRT have on the drug CL and efficacy of commonly administered drugs at the ICU? The findings aim to optimize therapeutic approaches in critically ill patients.
 

Aim is to investigate the occurence and prevention of anti-cancer treatment, particularly immune checkpoint inhibitors. 
 

1. Stress-relieving: 3D printing personalized cortisol for patients with adrenal insufficiency
2. A novel delayed release hydrocortison formulation for patients with adrenal insufficiency
3. Feasibility study of 10 mg 3D printed systained release hydrocortisone 
4. Feasibility study of 3D printed delayed release hydrocortisone 
5. RCT of novel 3D printed hydrocortisone vs standard of care in adrenal insufficiency 

A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critically ill pediatric patients and associated risk factors.