A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critically ill pediatric patients and associated risk factors.
This thesis explores how systemic inflammation and continuous renal replacement therapy (CRRT) influence drug pharmacokinetics in critically ill patients. Key research questions include: How does inflammation alter midazolam metabolism in critically ill COVID-19 patients? What impact does CRRT have on the drug CL and efficacy of commonly administered drugs at the ICU? The findings aim to optimize therapeutic approaches in critically ill patients.
Aim is to investigate the occurence and prevention of anti-cancer treatment, particularly immune checkpoint inhibitors.
A prospective observational PK/PD to study the target attainment for β-lactam antibiotics in critically ill pediatric patients and associated risk factors.
Binnen de oncologie wordt gepersonaliseerde therapie steeds gebruikelijker, onder andere door therapeutic drug monitoring (TDM). Dit onderzoek richt zich op gepersonaliseerde therapie met name binnen de urologische tumoren, bijvoorbeeld door een voedselinterventie studie of onderzoek van intrapatiëntvariatie in correlatie met therapiesucces.