Promotie onderzoek

To determine the need for repeated booster vaccinations in healthy individuals and to aid policymakers in future public health interventions for COVID-19. Gain insight into the immunogenicity of the additional bivalent booster vaccination in a representative sample of the healthy Dutch population. We aim to investigate three main topics: 
i) immunogenicity of bivalent vaccines after priming with adenovirus- or mRNA-based vaccines, 
ii) immunological recall responses and reactivity with relevant variants after booster vaccination, and 
iii) the necessity of booster vaccinations for the healthy population in the future.
 

We aim to develop models for sepsis detection and therapeutic treatment personalization, using mechanistic modelling and ML/AI approaches.
 

The aim is to improve the therapeutic drug monitoring process using drug dosing software and new laboratory techniques.
 

My research focuses on therapeutic drug monitoring of antipsychotics in children with an autism spectrum disorder, and adolescents with anorexia nervosa.
 

Fixed dosing strategies are commonly used in radio-ligand therapies. Radiation dosimetry provides a method of determining radiation exposure of various tissues, allowing for dosages to be optimized for individual patients. To this end, this project explores the use of radiation dosimetry in PK/PD modeling of radiopharmaceuticals, and its use in optimizing dosing strategies.
 

We aim to develop a pharmacometric model based on COVID-19 data able to identify personal characteristics that could predict individual immune response. Moreover, a framework will be established as a tool for pandemic preparedness.