Promotie onderzoek

All people living with HIV need life-long treatment with antiretroviral therapy (ART). However, ART coverage in children living with HIV continues to lag behind adults and many paediatric patients in sub-Saharan Africa still do not receive optimal paediatric treatment formulations or state-of-the-art drugs. Studies of efficacy and safety of these drugs in children have lagged behind, and the full range of appropriate formulations to treat younger children are yet to be developed for both first- and second-line treatments. 
 

We aim to develop models for sepsis detection and therapeutic treatment personalization, using mechanistic modelling and ML/AI approaches.
 

The aim is to improve the therapeutic drug monitoring process using drug dosing software and new laboratory techniques.
 

My research focuses on therapeutic drug monitoring of antipsychotics in children with an autism spectrum disorder, and adolescents with anorexia nervosa.
 

Fixed dosing strategies are commonly used in radio-ligand therapies. Radiation dosimetry provides a method of determining radiation exposure of various tissues, allowing for dosages to be optimized for individual patients. To this end, this project explores the use of radiation dosimetry in PK/PD modeling of radiopharmaceuticals, and its use in optimizing dosing strategies.
 

We aim to develop a pharmacometric model based on COVID-19 data able to identify personal characteristics that could predict individual immune response. Moreover, a framework will be established as a tool for pandemic preparedness. 
 

SPACe 2: STAR: An international, multicentre, randomized controlled trial (RCT) to evaluate the effect of therapeutic drug monitoring (TDM) of antipsychotic drugs in children and adolescents.