Promotie onderzoek

My research focuses on the socioeconomic determinants of psychotropic medication use in children and adolescents. Specifically, I aim to identify the complex relationships between socioeconomic factors and psychotropic medication use in young people, and to explore potential avenues for improving health outcomes in this vulnerable population.
 

My research focuses on the occurence of nocebo-effects in statin-intolerant. We try to identify patients who are statin-intolerant and that suffer from these effects. We hope that by identifying patients affected by the nocebo effect and allowing them to experientially understand its impact through an N=1 study design, they will experience fewer side effects from their statin treatment. This may help prevent the need to switch to expensive PCSK9 inhibitors.
 

We aim to identify, develop, and implement Health-IT solutions that improve prescribing.
 

Cost benefit analysis clinical medication reviews. Follow up of interventions from clinical pharmacists. Medication information needs of hospitalized patients.
 

1. Formulation development of direct, sustained and delayed release products using FDM, SSE and automated capsule filling systems. 
2. Quality and cost considerations of 3D printing in a hospital pharmacy setting.
3. Clinical implementation and studies of personalized cortisol in patients with adrenal insufficiency.
 

Hospital expenditure of expensive drugs increases yearly. In addition, shortages are becoming more common. To assure access to healthcare and treatment in the future, sustainable use of expensive drugs is very important. This research aims to optimize treatment with regard to efficacy and safety, while aiming to reduce drug costs. 
 

The aim of this project is to achieve more effective patient treatments with antibiotics by quantifying the concentrations at the site of infection with minimal sample volumes. To enable quantification of antibiotics at the site of infection, multiple assays should be developed and validated in these infected matrices, such as synovial fluid, synovial tissue, bone, and vitreous humor. Furthermore, the focus will be on small-volume samples and more patient friendly, and sustainable sample preparations.